Chameleon States: High-Valent Metal-Oxo Species of Cytochrome P450 and Its Ruthenium Analogue

2001 ◽  
Vol 40 (15) ◽  
pp. 2874-2878 ◽  
Author(s):  
François Ogliaro ◽  
Samüel P. de Visser ◽  
John T. Groves ◽  
Sason Shaik
Keyword(s):  
Cytochrome P450 ◽  
High Valent

Chameleon States: High-Valent Metal-Oxo Species of Cytochrome P450 and Its Ruthenium Analogue

2001 ◽  
Vol 113 (15) ◽  
pp. 2958-2962 ◽  
Author(s):  
François Ogliaro ◽  
Samüel P. de Visser ◽  
John T. Groves ◽  
Sason Shaik
Keyword(s):  
Cytochrome P450 ◽  
High Valent

Electrochemical generation of a high-valent state of cytochrome P450

2006 ◽  
Vol 100 (4) ◽  
pp. 519-523 ◽  
Author(s):  
Andrew K. Udit ◽  
Michael G. Hill ◽  
Harry B. Gray
Keyword(s):  
Cytochrome P450 ◽  
Electrochemical Generation ◽  
Valent State ◽  
High Valent

One small step for cytochrome P450 in its catalytic cycle, one giant leap for enzymology

2019 ◽  
Vol 23 (04n05) ◽  
pp. 358-366 ◽  
Author(s):  
Huriye Erdogan
Keyword(s):  
Cytochrome P450 ◽  
Time Course ◽  
Catalytic Cycle ◽  
Small Step ◽  
Compound I ◽  
Unique Role ◽  
Natural Time ◽  
Giant Leap ◽  
High Valent

The intermediates operating in the cytochrome P450 catalytic cycle have been investigated for more than half a century, fascinating many enzymologists. Each intermediate has its unique role to carry out diverse oxidations. Natural time course of the catalytic cycle is quite fast, hence, not all of the reactive intermediates could be isolated during physiological catalysis. Different high-valent iron intermediates have been proposed as primary oxidants: the candidates are compound 0 (Cpd 0, [FeOOH][Formula: see text]P450) and compound I (Cpd I, Fe(IV)[Formula: see text]O por[Formula: see text]P450). Among them, the role of Cpd I in hydroxylation is fairly well understood due the discovery of the peroxide shunt. This review endeavors to put the outstanding research efforts conducted to isolate and characterize the intermediates together. In addition to spectral features of each intermediate in the catalytic cycle, the oxidizing powers of Cpd 0 and Cpd I will be discussed along with most recent scientific findings.

scholarly journals Chameleon States: High-Valent Metal-Oxo Species of Cytochrome P450 and Its Ruthenium Analogue

2001 ◽  
Vol 113 (19) ◽  
pp. 3612-3612 ◽  
Author(s):  
François Ogliaro ◽  
Samüel P. de Visser ◽  
John T. Groves ◽  
Sason Shaik
Keyword(s):  
Cytochrome P450 ◽  
High Valent

Probing the Cytochrome P450-like Reactivity of High-Valent Oxo Iron Intermediates in the Gas Phase

2005 ◽  
Vol 44 (15) ◽  
pp. 5379-5387 ◽  
Author(s):  
M. Elisa Crestoni ◽  
S. Fornarini
Keyword(s):  
Cytochrome P450 ◽  
Gas Phase ◽  
High Valent
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